Childhood monosomy 7: epidemiology, biology, and mechanistic implications.
نویسندگان
چکیده
منابع مشابه
Mutations of the ras Proto - Oncogenes in Childhood
ras gene mutations are the most frequent molecular changes found in the preleukemic syndromes of adults and may play a role in initiating these diseases and in their progression to acute leukemia. However, little is known about the incidence or importance of these genetic mutations in childhood myeloproliferative states (MPS). The bone marrow (BM) monosomy 7 syndrome accounts for a large percen...
متن کاملMutations of the ras proto-oncogenes in childhood monosomy 7.
ras gene mutations are the most frequent molecular changes found in the preleukemic syndromes of adults and may play a role in initiating these diseases and in their progression to acute leukemia. However, little is known about the incidence or importance of these genetic mutations in childhood myeloproliferative states (MPS). The bone marrow (BM) monosomy 7 syndrome accounts for a large percen...
متن کاملHereditary hyperferritinemia-cataract syndrome: two novel mutations in the L-ferritin iron-responsive element.
ogy of cytomegalovirus infections during pregnancy and infancy. Scand J Infect Dis 10:165, 1987 11. Ahlfors K, Ivarsson S-A, Johnsson T, Svensson I: Congenital and acquired cytomegalovirus infections. Acta Paediatr Scand 67:321, 1978 12. Stuart-Harris C: The epidemiology and clinical presentation of herpes virus infections. J Antimicrob Chemother 12:1, 1983 13. Lamy ME, Favart AM, Cornue C, Men...
متن کامل-7/del(7q) in childhood
Several clinical forms: the most frequents are JCML and the monosomy 7 syndrome; these disorders have some common features: JCML is defined by clinical and cytological observations; 6 to 24% of JCML children show monosomy 7 in the bone marrow; monosomy 7 syndrome is a cytogenetic-defined entity. The therapy related cases of monosomy 7 had been exposed to alkylating agents, they have a myelodysp...
متن کاملTranslocation t(8;22) and monosomy 7 in a case of acute lymphoblastic leukemia expressing myeloid markers.
The simultaneous coexpression of lymphoid and myeloid markers has been observed in some cases of childhood acute lymphoblastic leukemias (ALL). In this paper, we describe a 6-year-old male patient with an ALL expressing myeloid antigens in whom a novel karyotypic association, t(8;22) and monosomy 7, and high Ag-NOR activity were found concomitantly with a very short survival.
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ورودعنوان ژورنال:
- Blood
دوره 85 8 شماره
صفحات -
تاریخ انتشار 1995